@article{204376,
  author = {Alexander Frese and Andrea Mariossi and Michael Levine and Martin W{\"u}hr},
  title = {Quantitative proteome dynamics across embryogenesis in a model chordate},
  abstract = {<p>The evolution of gene expression programs underlying the development of vertebrates remains poorly characterized. Here, we present a comprehensive proteome atlas of the model chordate Ciona, covering eight developmental stages and 7,000 translated genes, accompanied by a multi-omics analysis of co-evolution with the vertebrate Xenopus. Quantitative proteome comparisons argue against the widely held hourglass model, based solely on transcriptomic profiles, whereby peak conservation is observed during mid-developmental stages. Our analysis reveals maximal divergence at these stages, particularly gastrulation and neurulation. Together, our work provides a valuable resource for evaluating conservation and divergence of multi-omics profiles underlying the diversification of vertebrates.Competing Interest StatementThe authors have declared no competing interest.</p>
},
  year = {2023},
  journal = {bioRxiv},
  publisher = {Cold Spring Harbor Laboratory},
  url = {https://www.biorxiv.org/content/early/2023/10/06/2023.10.04.559613},
  doi = {10.1101/2023.10.04.559613},
}