@article{204396,
  keywords = {Proteome, Transcriptome, Development, Evolution, Chordates, Vertebrates},
  author = {Alexander Frese and Andrea Mariossi and Michael Levine and Martin W{\"u}hr},
  title = {Quantitative proteome dynamics across embryogenesis in a model chordate},
  abstract = {<p>Summary The evolution of gene expression programs underlying the development of vertebrates remains poorly characterized. Here, we present a comprehensive proteome atlas of the model chordate Ciona, covering eight developmental stages and \~{}7,000 translated genes, accompanied by a multi-omics analysis of co-evolution with the vertebrate Xenopus. Quantitative proteome comparisons argue against the widely held hourglass model, based solely on transcriptomic profiles, whereby peak conservation is observed during mid-developmental stages. Our analysis reveals maximal divergence at these stages, particularly gastrulation and neurulation. Together, our work provides a valuable resource for evaluating conservation and divergence of multi-omics profiles underlying the diversification of vertebrates.</p>
},
  year = {2024},
  journal = {iScience},
  pages = {109355},
  issn = {2589-0042},
  url = {https://www.sciencedirect.com/science/article/pii/S2589004224005765},
  doi = {10.1016/j.isci.2024.109355},
}