@article{56986,
  keywords = {Animals, Humans, Cell Line, Carrier Proteins, Mice, Female, CDC2 Protein Kinase, Xenopus, Cell Cycle Proteins, Endopeptidases, Histones, Meiosis, Neoplasm Proteins, Oocytes, Securin, Separase},
  author = {Ingo Gorr and Alexandra Reis and Dominik Boos and Martin W{\"u}hr and Suzanne Madgwick and Keith Jones and Olaf Stemmann},
  title = {Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes.},
  abstract = {<p>Separase not only triggers anaphase of meiosis I by proteolytic cleavage of cohesin on chromosome arms, but in vitro vertebrate separase also acts as a direct inhibitor of cyclin-dependent kinase 1 (Cdk1) on liberation from the inhibitory protein, securin. Blocking separase-Cdk1 complex formation by microinjection of anti-separase antibodies prevents polar-body extrusion in vertebrate oocytes. Importantly, proper meiotic maturation is rescued by chemical inhibition of Cdk1 or expression of Cdk1-binding separase fragments lacking cohesin-cleaving activity.</p>
},
  year = {2006},
  journal = {Nat Cell Biol},
  volume = {8},
  pages = {1035-7},
  month = {09/2006},
  issn = {1465-7392},
  doi = {10.1038/ncb1467},
  language = {eng},
}