Laboratory for Systems Biochemistry

Welcome to the Wühr Lab!

We aim to advance quantitative proteomics technology and use it with other approaches to elucidate principles of cellular organization on a systems level.

Back, from left: Edward Cruz, Argit Marishta, Vyas Pujari, Felix Keber, Aleigha Reynolds, Bhoomika Chowdhary, Jessica Dong,

Front, from left: Audrey Zhu, Alex Frese, Alex Johnson, Martin Wühr, Chirag Kumar, Meera Gupta.

Yang, Liu, Audrey Zhu, Javed Aman, David Denberg, Marcus Kilwein, Robert Marmion, Alex Johnson, et al. (2024) 2024. “ERK Synchronizes Embryonic Cleavages in Drosophila.”. Developmental Cell. doi:10.1016/j.devcel.2024.08.004.

Gupta, Meera, Alex Johnson, Edward Cruz, Eli Costa, Randi Guest, Sophia Li, Elizabeth Hart, et al. (2024) 2024. “Global Protein Turnover Quantification in Escherichia Coli Reveals Cytoplasmic Recycling under Nitrogen Limitation.”. Nature Communications 15 (1): 5890. doi:10.1038/s41467-024-49920-8.

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Arunachalam, Easun, Felix C. Keber, Richard C. Law, Chirag K. Kumar, Yihui Shen, Junyoung O. Park, Martin Wühr, and Daniel J. Needleman. 2024. “Robustness of Mitochondrial Biogenesis and Respiration Explain Aerobic Glycolysis”. BioRxiv. Cold Spring Harbor Laboratory. doi:10.1101/2024.07.04.601975.

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Shen, Yihui, Hoang V. Dinh, Edward R. Cruz, Zihong Chen, Caroline R. Bartman, Tianxia Xiao, Catherine M. Call, et al. 2024. “Mitochondrial ATP Generation Is More Proteome Efficient Than Glycolysis”. Nature Chemical Biology. doi:10.1038/s41589-024-01571-y.

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