Laboratory for Systems Biochemistry

Welcome to the Wühr Lab!

We aim to advance quantitative proteomics technology and use it with other approaches to elucidate principles of cellular organization on a systems level.

Back, from left: Edward Cruz, Argit Marishta, Vyas Pujari, Felix Keber, Aleigha Reynolds, Bhoomika Chowdhary, Jessica Dong,

Front, from left: Audrey Zhu, Alex Frese, Alex Johnson, Martin Wühr, Chirag Kumar, Meera Gupta.

Johnson, Alex, Jingjing Huang, Argit Marishta, Edward Cruz, Andrea Mariossi, William Barshop, Jesse Canterbury, et al. (2025) 2025. “Sensitive and Accurate Proteome Profiling of Embryogenesis Using Real-Time Search and TMTproC Quantification.”. Molecular & Cellular Proteomics : MCP, 100899. doi:10.1016/j.mcpro.2024.100899.

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Benn, Georgina, Carolina Borrelli, Dheeraj Prakaash, Alex N. T. Johnson, Vincent A. Fideli, Tahj Starr, Dylan Fitzmaurice, et al. 2024. “OmpA Controls Order in the Outer Membrane and Shares the Mechanical Load”. Proceedings of the National Academy of Sciences 121: e2416426121. doi:10.1073/pnas.2416426121.

Yang, Liu, Audrey Zhu, Javed Aman, David Denberg, Marcus Kilwein, Robert Marmion, Alex Johnson, et al. (2024) 2024. “ERK Synchronizes Embryonic Cleavages in Drosophila.”. Developmental Cell. doi:10.1016/j.devcel.2024.08.004.

Gupta, Meera, Alex Johnson, Edward Cruz, Eli Costa, Randi Guest, Sophia Li, Elizabeth Hart, et al. (2024) 2024. “Global Protein Turnover Quantification in Escherichia Coli Reveals Cytoplasmic Recycling under Nitrogen Limitation.”. Nature Communications 15 (1): 5890. doi:10.1038/s41467-024-49920-8.

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